Polyclonal gammopathy related to renal bleeding in a peritoneal dialysis patient / 소아과

Polyclonal gammopathy represents the diffuse activation of B cells and is usually related to inflammation or immune-related diseases. However, the mechanisms leading to polyclonal gammopathy are essentially speculative. Generally, infectious, inflammatory, or various other reactive processes may be indicated by the presence of a broad-based peak or band in the gamma region on serum protein electrophoresis results. A 15-year-old girl, who had been receiving peritoneal dialysis, presented with polyclonal gammopathy and massive gross hematuria. Renal artery embolization was performed, after which the continuous bleeding subsided and albumin-globulin dissociation resolved. This is a rare case of polyclonal gammopathy related to renal bleeding.

The Clinical Analysis of Paroxysmal Kinesigenic Dyskinesia

PURPOSE: Paroxysmal kinesigenic dyskinesia (PKD) is one of the movement disorders in which dyskinesia occurs in a part of the body by a sudden movement after a rest under a tension or a stress. This study was aimed to evaluate the clinical features of children and adolescents with PKD in Korea via analysing the patients who have treated in Department of Pediatrics, Kyungpook National University Hospital. METHODS: A total of seven children with PKD was involved in the study and their medial records were retrospectively evaluated. RESULTS: The mean age of the 7 subjects was 15.7 years (10.0-21.4 years old). The male to female ratio was 6:1. They presented with dystonia with the average duration of 10.5 seconds (3.5-17.5 seconds), which triggered by various sudden movements. No accompanying cormorbidities were noted. Their laboratory findings were unremarkable. Six of the patients, except one who refused treatment with medicine, responded well to medication and remained symptom free. The average time response to medication was 3.4 weeks (0.95-7.81 weeks). They were of treated with either oxcarbazepine (n=4, 14.9+/-5.8 mg/kg/day) or lamotrigine (n=2, 1.5+/-0.9 mg/kg/day). There was no significant difference between two groups in terms of age, response, adverse events, and so on. CONCLUSION: This study showed that clinical features of Korean children with PKD are quite similar to those of other countries. They responded well to the medication. In addition, lamotrigine can be an alternative choice for the treatment.

Clinical Characteristics and Genotype of Rotavirus Infection in Newborn Infants / 대한주산의학회잡지

PURPOSE: This study was conducted to investigate the incidence of rotavirus infection and common rotavirus strains of newborn infants admitted to the NICU and elucidate association, between rotavirus infection and clinical symptoms, and the significance of rotavirus antigen test. METHODS: From July 2010 to June 2011, stools of 408 newborns admitted into the NICU were tested for rotavirus antigen by enzyme-linked fluorescent assay. Rotavirus positive stools were performed RT-PCR. RESULTS: A total of 408 stool samples were examined by VIDAS Rotavirus(R), and 128 specimens (31.4%) were proven positive. One hundred thirteen fecal specimens were eligible for RT-PCR and rotavirus was detected in 42 samples (10.3%). PCR (+) prevalence of antigen positive infants was significantly lower in 1-2 postnatal days group than infants older than three days after birth (P<0.001). Out of the 42 PCR positive infants, there were 26 (62%) symptomatic infants. Seventeen infants had fever, 15 had diarrhea, and 3 experienced vomiting. Rest of the 16 patients (38%) did not show any symptoms. The most common strain was G4P[6] (n=40, 95.2%), followed by G4P[8] (n=1, 2.4%), and G3P[3] (n=1, 2.4%). CONCLUSIONS: Rotavirus infection rate in the NICU was 31.4% in the antigen test and 11.7% in the PCR test. False positive rate of rotavirus antigen test was significantly higher in 1-2 postnatal days group. Thus, it should be considered to apply different RFV standards from adults when rotavirus antigen test result is evaluated in newborn infants. The most common strain of rotavirus was G4P[6].